Laboratory of Sensory Systems
The lab focuses on understanding the molecular and functional basis underlying the evolutionary diversity of sensory receptor proteins from natural biological systems.
The lab focuses on understanding the molecular and functional basis underlying the evolutionary diversity of sensory receptor proteins from natural biological systems.
We merge transcriptomic, molecular and functional approaches to explore the structure-function relationships of natural visual and non-visual GPCR opsins, and investigate the effect of mutations on spectral tuning in an evolutionary and translational framework.
Molecular and functional modulation of thermosensitive TRP channels by natural repellent ligands in disease vectors.
Selected publications
Valencia-Montoya WA, Liénard MA, Rosser N, Calonje M, Salzman S, Tsai CC, Yu N, Carlson JR, Cogni R, Pierce NE, Bellono NW. (2025). Infrared radiation is an ancient pollination signal. Science 390:1164-1170. 10.1126/science.adz1728 | Science Perspective Evolutionary Biology | Podcast Avec la Science | NYTimes
Liénard MA*, Báez-Nieto D*, Tsai CC, Valencia-Montoya WA, Werin B, Johansson U, Lassance JM, Pan JQ, Yu NF, Pierce NE (2024). TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect. iScience 109541. *equal contributions. doi.org/10.1016/j.isci.2024.109541
Roberts NS, Svensson EI, Liénard MA (2025). Opsin gene expression plasticity and spectral sensitivity as mechanisms for search image formation in male damselflies. Proceedings Biological Sciences 292, 20242511. doi.org/10.1098/rspb.2024.2511
Liénard MA, Valencia-Montoya WA, Pierce NE (2022). Molecular advances to study the function, evolution, and spectral tuning of arthropod visual opsins. Philosophical transactions B. 377 (20210279). doi.org/10.1098/rstb.2021.0279
Liénard MA, Bernard GD, Allen AA, Lassance JM, Song S*, Childers Rabideau R, Yu NF, Ye D*, Stephenson A*, Valencia-Montoya WA, Salzman S, Whitaker MRL, Calonje M, Zhang F, Pierce NE. (2021). The evolution of red colour vision is linked to coordinated rhodopsin tuning in lycaenid butterflies. Proceedings of the National Academy of Sciences USA 118: e2008986118. *undergraduate students supervised by Marjorie Liénard. doi.org/10.1073/pnas.2008986118
Marjorie Lienard